G.729 Error Recovery for Internet Telephony

This memorandum discusses the use of the ITU G.729 CS-ACELP speech coder on the Internet for telephony applications. In particular, the memo explores issues of error resiliency and recovery. In particular, the paper considers two questions. First, given N consecutive frame erasures (due to packet losses), how long does the decoder take to resynchronize its state with the encoder? What is the strength of the resulting error signal, both in terms of objective and subjective measures? The second issue explores which particular factors contribute to the strength of the error signal: the distortion of the speech due to the incorrect concealment of the erasures, or the subsequent distortion due to the loss of state synchronization, even though correct packets are being received. Both objective and subjective measures are used to characterize the importance of each of these two factors

Programming Internet Telephony Services

Internet telephony enables a wealth of new service possibilities. Traditional telephony services, such as call forwarding, transfer, and 800 number services, can be enhanced by interaction with email, web, and directory services. Additional media types, like video and interactive chat, can be added as well. One of the challenges in providing these services is how to effectively program them. Programming these services requires decisions regarding where the code executes, how it interfaces with the protocols that deliver the services, and what level of control the code has. In this paper, we consider this problem in detail. We develop requirements for programming Internet telephony services, and we show that at least two solutions are required --- one geared for service creation by trusted users (such as administrators), and one geared for service creation by untrusted users (such as consumers). We review existing techniques for service programmability in the Internet and in the telephone network,and extract the best components of both. The result is a Common Gateway Interface (CGI) that allows trusted users to develop services, and the Call Processing Language (CPL) that allows untrusted users to develop services

Signaling for Internet Telephony

Internet telephony must offer the standard telephony services.However, the transition to Internet-based telephony services also provides an opportunity to create new services more rapidly and with lower complexity than in the existing public switched telephone network(PSTN). The Session Initiation Protocol (SIP) is a signaling protocol that creates, modifies and terminates associations between Internet end systems, including conferences and point-to-point calls. SIP supports unicast, mesh and multicast conferences, as well as combinations of these modes. SIP implements services such as call forwarding and transfer, placing calls on hold, camp-on and call queueing by a small set of call handling primitives. SIP implementations can re-use parts of other Internet service protocols such as HTTP and the Real-Time Stream Protocol (RTSP). In this paper, we describe SIP, and show how its basic primitives can be used to construct a wide range of telephony services

Using Population Mixtures to Optimize the Utility of Genomic Databases: Linkage Disequilibrium and Association Study Design in India

When performing association studies in populations that have not been the focus of large-scale investigations of haplotype variation, it is often helpful to rely on genomic databases in other populations for study design and analysis – such as in the selection of tag SNPs and in the imputation of missing genotypes. One way of improving the use of these databases is to rely on a mixture of database samples that is similar to the population of interest, rather than using the single most similar database sample. We demonstrate the effectiveness of the mixture approach in the application of African, European, and East Asian HapMap samples for tag SNP selection in populations from India, a genetically intermediate region underrepresented in genomic studies of haplotype variation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65949/1/j.1469-1809.2008.00457.x.pd

Slowing of Magnetic Reconnection Concurrent with Weakening Plasma Inflows and Increasing Collisionality in Strongly Driven Laser-Plasma Experiments

An evolution of magnetic reconnection behavior, from fast jets to the slowing of reconnection and the establishment of a stable current sheet, has been observed in strongly driven, β ≲ 20 laser-produced plasma experiments. This process has been inferred to occur alongside a slowing of plasma inflows carrying the oppositely directed magnetic fields as well as the evolution of plasma conditions from collisionless to collisional. High-resolution proton radiography has revealed unprecedented detail of the forced interaction of magnetic fields and super-Alfvénic electron jets (V[subscript jet] ~ 20V[subscript A]) ejected from the reconnection region, indicating that two-fluid or collisionless magnetic reconnection occurs early in time. The absence of jets and the persistence of strong, stable magnetic fields at late times indicates that the reconnection process slows down, while plasma flows stagnate and plasma conditions evolve to a cooler, denser, more collisional state. These results demonstrate that powerful initial plasma flows are not sufficient to force a complete reconnection of magnetic fields, even in the strongly driven regime.United States. Dept. of Energy (Grant DE-NA0001857)University of Rochester. Laboratory for Laser Energetics (Grant 415935-G)National Laser User’s Facility (Grant DE-NA0002035)University of Rochester. Fusion Science Center (Grant 5-24431

Safety and feasibility of a home-based six week resistance training program in juvenile idiopathic arthritis

BACKGROUND: Juvenile idiopathic arthritis (JIA), among the most common chronic diseases of childhood, can be associated with attenuated physical activity levels, reduced fitness, decreased functionality and pain. This pilot study aimed to determine the safety, feasibility and effect of a six week resistance training program in children with JIA. METHODS: Youth (8-18 years) with JIA participated in a home-based resistance training program. Participants reported pain on an electronic diary once a day for one week prior to training, then once a day on non-exercise days and three times a day (before-exercise, after-exercise, and end-of-day) on exercise days for the subsequent six weeks of training. Secondary outcome measures included inflammation (assessed by ultrasound), muscle size (assessed by ultrasound), muscle strength (assessed by dynamometer) and functional ability (assessed by childhood health assessment questionnaire), measured at baseline and post-training. Participants were also instructed to wear an accelerometer one week prior to training to estimate baseline physical activity levels. Statistical analyses included safety (pain changes and any adverse events), feasibility (adherence to program and modifications made to exercises) and effect of program (differences in secondary measures pre and post training). An alpha level of p < 0.05 was accepted as significant. RESULTS: Seven participants completed an average of 12.7 ± 3.4 (range 8-17) exercise sessions out of a possible 18 (70.6%). No adverse events were reported and pain did not increase over the seven weeks. Secondary measures revealed a significant increase in vastus lateralis thickness from pre to post training (p < 0.05). End-of-day pain intensity was correlated to end-of-day stiffness, fatigue and mood (r = .864, r = .581, r = -.637, respectively, p < 0.001). Pain intensity was also correlated with ratings of perceived exertion of the exercise (r = 0.324, p < 0.01). Only two children met the recommended 60 minutes of moderate to vigorous physical activity per day. CONCLUSIONS: A six week home-based resistance training program is both safe (absence of pain changes or adverse events over the six weeks) and feasible (comparable adherence rates to other exercise studies involving JIA and individually modifiable) in children with JIA

Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells

Marcus Altfeld and colleagues suggest that the exhaustion of virus-specific CD8+ T cells during chronic HIV infection likely results from the persistence of antigen

HIV-1 persistence in CD4+ T cells with stem cell-like properties

Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM) harbor high per-cell levels of HIV-1 DNA, and make increasing contributions to the total viral CD4+ T cell reservoir over time. Moreover, phylogenetic studies suggested long-term persistence of viral quasispecies in CD4+ TSCM cells. Thus, HIV-1 may exploit stem cell characteristics of cellular immune memory to promote long-term viral persistence

Inference of population splits and mixtures from genome-wide allele frequency data

Many aspects of the historical relationships between populations in a species are reflected in genetic data. Inferring these relationships from genetic data, however, remains a challenging task. In this paper, we present a statistical model for inferring the patterns of population splits and mixtures in multiple populations. In this model, the sampled populations in a species are related to their common ancestor through a graph of ancestral populations. Using genome-wide allele frequency data and a Gaussian approximation to genetic drift, we infer the structure of this graph. We applied this method to a set of 55 human populations and a set of 82 dog breeds and wild canids. In both species, we show that a simple bifurcating tree does not fully describe the data; in contrast, we infer many migration events. While some of the migration events that we find have been detected previously, many have not. For example, in the human data we infer that Cambodians trace approximately 16% of their ancestry to a population ancestral to other extant East Asian populations. In the dog data, we infer that both the boxer and basenji trace a considerable fraction of their ancestry (9% and 25%, respectively) to wolves subsequent to domestication, and that East Asian toy breeds (the Shih Tzu and the Pekingese) result from admixture between modern toy breeds and "ancient" Asian breeds. Software implementing the model described here, called TreeMix, is available at http://treemix.googlecode.comComment: 28 pages, 6 figures in main text. Attached supplement is 22 pages, 15 figures. This is an updated version of the preprint available at http://precedings.nature.com/documents/6956/version/

Observation of a Reflected Shock in an Indirectly Driven Spherical Implosion at the National Ignition Facility

A 200  μm radius hot spot at more than 2 keV temperature, 1  g/cm[superscript 3] density has been achieved on the National Ignition Facility using a near vacuum hohlraum. The implosion exhibits ideal one-dimensional behavior and 99% laser-to-hohlraum coupling. The low opacity of the remaining shell at bang time allows for a measurement of the x-ray emission of the reflected central shock in a deuterium plasma. Comparison with 1D hydrodynamic simulations puts constraints on electron-ion collisions and heat conduction. Results are consistent with classical (Spitzer-Harm) heat flux.United States. Dept. of Energy (Contract DE-AC52-07NA27344)Brookhaven National Laboratory (Laboratory Directed Research and Development Grant 11-ERD-050